Study on PTTG?C-MYC Expression in Colorectal and Their ...

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Tumor Research

[Abstract]

Objective:It has been taken more and more attention to the function of the abnormal activation and expression of oncogene for the development of colorectal cancer(CRC).It has been discovered in recent years that there are many kinds of the activation of oncogene such as C-MYC and the inactivation of tumor suppressor gene such as p53 in CRC.Pituitary tumor transforming gene(PTTG)was a newly reported oncogene.Overexpression of PTTG play a great role in promoting cell proliferation,transformation and tumorigenesis,It has been ensured that C-MYC was an important down-stream target for PTTG,and overexpression of C-MYC was related to tumorigenesis including CRC.Here we detected the expression of PTTG in human colorectal cancer and its correlation with C-MYC and its significance in cancer biological characteristics to detect its role in colorectal carnoma.Methods:The expression of PTTGmRNA and PTTG protein were evaluated in nomal colorectal tissures,colorectal adenomas and colorectal cancers by reverse transcription polymerase chain reaction(RT-PCR)and immunohistochemistry(IHC).The result of the exmation was statistically analyzed. Results:1.We has detected the expression of PTTGmRNA in nomal colorectal tissures,colorectal adenomas and colorectal cancers.The expression was significant between these three groups.The expression in colorectal cancers was significantly higher than that in colorectal adenomas and nomal colorectal tissures,and the expression of PTTGm RNA in colorectal adenimas was also significantly higher than in nomal colorectal tissures.2.The expression of PTTG protein in colorectal cancer was significantly higher than in colorectal adenimas and nomal colorectal tissures,and the expression in colorectal adenimas was also significantly higher than in nomal colorectal tissures.We hasn?t detected the expression of PTTG protein in nomal colorectal tissures.3.The expression of PTTGmRNA and PTTG protein was related,to Dukes stages.The expression of PTTGmRNA was related to lymph node metastasis.4.There was a positive correlation between the expression of PTTG protein and C-MYC protein in colorectal tissures.Conclusions:PTTG may play an important role in carcinogenesis and development of human colorectal cancer by the investigate of the expression of PTTG in colorectal cancers and its realation with C-MYC.

Title: Study on PTTG?C-MYC Expression in Colorectal and Their Correlation

Category: Brain Tumor

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Source: http://www.tumorres.com/brain-tumor/35094.htm

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The Real Disaster: Three Reasons Why DR to the Cloud Can Fail ...

Words by: Ziv Kedem

1. The replication technologies used by your Cloud Service Provider may slow down your IT environment.
   Many replication technologies utilize snapshots to make a copies of data, slowing production environments and taking resources from your critical applications and systems. Disaster Recovery, as important as it is, should not hinder your critical business systems.
2. Most Cloud service providers charge for bandwidth utilized to send data to their Cloud, resulting in a costly expense.
   Many replication solutions do not have built-in compression and network optimization tools. Replication without compression can become quite costly, as network costs are often quoted by service providers on a per-GB (gigabyte) basis.
3. Your service provider?s Cloud-based replication site needs to work with your existing storage and technologies.

Currently, Cloud service providers need to offer the same storage and technologies as their customers in order to serve as a replication and recovery site. If you and your Cloud provider are using different storage and technologies, the process of replicating data to their cloud can be costly and involve some complex, manual processes.

What can you do to make sure your company does not fall victim to failures in these key areas?

1. Avoid snapshots and other replication technologies that tax production.
   A disaster recovery solution should be simple, automated and have zero impact on your business systems and applications. Be sure to have an automated mechanism for testing your DR solution as well, so that you can run regular checks of your protected data. Data protection and tests of your DR system should never impact the applications running in your data center.
2. Find a replication solution with built-in bandwidth compression.
   Compression is key to low bandwidth utilization and keeping costs down. Find a provider that works with you to keep network utilization down, by compressing replication data and helping you to prioritize the data that is most important to you. Some providers even have tools to help keep the data protection setup costs down, in order to avoid a costly hit to the network when setting up your replication solution.
3. Make sure your Cloud provider can work with any storage technologies.
   Your Cloud provider will need to offer the ability to mix storage from any vendor using any technology, so that your data and the data of all of their many customers can be protected in their Cloud. Make sure they are set up to do this, otherwise you?ll end up paying for them to upgrade their storage technology to match yours. Plus, if the Cloud provider can only work with one storage vendor, that locks you to a specific vendor in your data center for the full duration of your Cloud contract. Make sure your provider can support any storage vendor, so you have the freedom to upgrade or change vendors in your data center without disrupting your Cloud DR plan.

Disaster Recovery to the Cloud is a big opportunity for SMBs, offering secure, automated, and low-cost data replication and recovery. Simply knowing what to ask your Cloud provider will make the selection of DR services simple and effective.

About the Author:

Ziv Kedem is co-founder and CEO of Zerto, a company providing disaster recovery and business continuity solutions for virtualized data centers and Cloud environments.

Source: http://thecloudmagazine.com/real-disaster-reasons-dr-cloud-fail/

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Obama seeks corporate tax rate cut, loophole limit

President Barack Obama, accompanied by Vice President Joe Biden, talks about the importance of the payroll-tax cut and jobless-benefits extension compromise that bi-partisan House and Senate conferees reached last week, Tuesday, Feb. 21, 2012, in the Eisenhower Executive Office Building on the White House complex in Washington. (AP Photo/J. Scott Applewhite)

President Barack Obama, accompanied by Vice President Joe Biden, talks about the importance of the payroll-tax cut and jobless-benefits extension compromise that bi-partisan House and Senate conferees reached last week, Tuesday, Feb. 21, 2012, in the Eisenhower Executive Office Building on the White House complex in Washington. (AP Photo/J. Scott Applewhite)

WASHINGTON (AP) ? President Barack Obama on Wednesday proposed a lower corporate tax rate and an end to dozens of loopholes he said helps U.S. companies move jobs and profits overseas. "It's not right and it needs to change," he said.

The president wants to lower the U.S. corporate tax rate from the current 35 percent, the highest in the world after Japan. Under his plan, manufacturers would receive incentives so that their effective tax rate could be even lower.

Obama's election-year plan would set a new 28 percent corporate tax rate, still higher than the 25 percent rate sought by congressional Republicans.

"It's a framework that lowers the corporate tax rate and broadens the tax base in order to increase competitiveness for companies across the nation," Obama said in a statement.

Corporations would have to give up dozens of cherished loopholes and subsidies that they now enjoy. Corporations with overseas operations would also face an unspecified minimum tax on their foreign earnings.

The proposal outlined by Geithner would also eliminate tax loopholes and subsidies that Geithner called "fundamentally unfair."

Obama also would set a minimum tax on the foreign earning of U.S. companies.

Chances of accomplishing such change in the tax system are slim in a year dominated mostly with presidential and congressional elections. But for Obama, the proposal is part of a larger tax plan that is central to his re-election strategy.

Treasury Secretary Timothy Geithner, who rolled out the plan Wednesday morning, acknowledged that the debate "will be politically contentious."

"Some will say these proposals are too tough on business, and others will say that they're not tough enough," he said.

Obama's plan would be part of a larger effort to overhaul the U.S. tax system, and it dovetails with Obama's call for raising taxes on millionaires and maintaining current rates on individuals making $200,000 or less. But White House spokesman Jay Carney said Congress could act separately on the corporate tax component of Obama's overall tax strategy.

Republican reaction was mixed. House Ways and Means Committee Chairman Dave Camp said he appreciated the administration's plan, though it set a corporate tax rate that is higher than the 25 percent he has proposed. He faulted Obama, however, for not offering a wholesale overhaul of the entire tax system for businesses and individuals.

"While this is a good step by the administration, I will borrow from the president's own words to Congress from just yesterday: 'Don't stop here. Keep going,'" Camp said in a statement. But Sen. Orrin Hatch, the top Republican on the Senate Finance Committee, dismissed the president's plan as a "set of bullet points designed more for the campaign trail than an actual blueprint for fixing our tax code."

While the 35 percent nominal corporate tax rate ranks among the highest, deductions, credits and exemptions allow many corporations to pay taxes at a much lower rate.

Under the framework proposed by the administration, the rate cuts, closed loopholes and the minimum tax on overseas earning would result in no increase to the deficit.

That means that many businesses that slip through loopholes or enjoy subsidies and pay an effective tax rate that is substantially less than the 35 percent corporate tax could end up paying more under Obama's plan. Others, however, would pay less while some would simply benefit from a more simplified system.

Reducing the corporate tax rate from 35 percent to 28 percent would reduce tax revenues by about $700 billion over the next decade, according to an estimate prepared in October by the Joint Committee on Taxation, the official scorekeeper for Congress.

That means lawmakers would have to find about $70 billion a year in tax increases to keep the package from adding to the budget deficit, hardly an easy task. In 2010, the corporate income tax raised a total of $278 billion, according to the Internal Revenue Service. Corporate income taxes have been shrinking as a share of overall federal taxes for decades. In 2010, corporate income taxes made up just 12 percent of all federal tax receipts, down from 24 percent in 1960, according to the IRS.

Geithner said the Obama plan aims to help U.S. businesses, especially manufacturers who face strong international competition. Obama's plan would lower the effective rate for manufacturers to 25 percent by offering other tax incentives that emphasize development of clean energy systems.

Many members of both parties have said they favor overhauling the nation's individual and corporate tax systems, which they complain have rates that are too high and are riddled with too many deductions.

The corporate tax debate has made its way into the presidential contest. Former Massachusetts Gov. Mitt Romney has called for a 25 percent rate, former House Speaker Newt Gingrich would cut the corporate tax rate to 12.5 percent, and former Sen. Rick Santorum would exempt domestic manufacturers from the corporate tax and halve the top rate for other businesses.

While Obama has been promoting various aspects of his economic agenda in personal appearances and speeches, the decision to leave the corporate tax plan to the Treasury Department to unveil signaled its lower priority.

What's more, the administration's framework leaves much for Congress to decide ? a deliberate move by the administration to encourage negotiations but which also doesn't subject the plan to detailed scrutiny.

Obama's plan is not as ambitious as a House Republican proposal that would lower the corporate rate to 25 percent.

Still, Obama has said corporate tax rates are too high and has proposed eliminating tax breaks for American companies that move jobs and profits overseas. He also has proposed giving tax breaks to U.S. manufacturers, to firms that return jobs to this country and to companies that relocate to some communities that have lost big employers.

Geithner told a House committee last week that the administration wants to create more incentives for corporations to invest in the United States.

"We want to bring down the rate, and we think we can, to a level that's closer to the average of that of our major competitors," Geithner told the House Ways and Means Committee.

White House economic adviser Gene Sperling has advocated a minimum tax on global profits. Currently many corporations do not invest overseas profits in the United States to avoid the 35 percent tax rate.

___

Associated Press writers Martin Crutsinger and Stephen Ohlemacher contributed to this report.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2012-02-22-Obama-Corporate%20Taxes/id-bb6e0969d80f49ffb1ba3a35383b86ef

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Make Your Pregnancy A Great Time By Following These Great Tips ...

Single mothers need to prepare for a baby?s arrival and may need a little more help from friends and family than a married mother. Regardless of the situation, everyone can use a bit of advice for helping any mother prepare for the arrival of a baby into a home, and the following article will help you help the new mother.

To help avoid some of the pregnancy back pain, keep lifting to a minimum. When lifting small items, squat and lift with your legs. Try to avoid lifting large objects and don?t bend at the waist as this puts strain on your back muscles. The best idea is to ask for help when you feel you need it.

Late pregnancy back pain is a reality that most women have to deal with. In order to minimize the pain, you need to have a massage to help loosen the muscles. If massage is not an option, pelvic tilts or hot compresses will also work very well to relieve some of the pressure.

Use a birth ball during pregnancy to stay fit. You can sit on the ball instead of the sofa to strengthen your muscles. It will help you keep your posture straight which will help in preventing the aches and pains that come from bad posture. You can also use it after pregnancy as well to get back into the swing of things.

When you are pregnant, you will want to limit the amount of alcohol that you consume. This means that when you are out with your friends, you will need to become more responsible for the sake of your baby. Practice good drinking habits to maximize the success of your pregnancy.

When you are pregnant, it is important that you continue to exercise. Exercise helps reduce the chances of miscarriage and has been prove to help ease the length and pains of labor and delivery. Also, by exercising when you are pregnant, you will help keep off the weight you may gain.

Keep your teeth in good shape and continue to visit your dentist when you are pregnant. Pregnancy is actually known to cause many dental problems, including gingivitis. Make sure that you continue to brush your teeth twice a day and use dental floss along with mouthwash. Visit your dentist with any problems.

Make sure you are educated about pregnancy. There are so many books and websites that you can read that will help you out. If you know what is supposed to be going on, it will calm your nerves, and you will also be able to tell if something is wrong.

Incorporate safe exercise activities into your daily routine. Exercise is crucial to helping pregnant women feel better, sleep better, and control their weight. Consider engaging in exercises like yoga, swimming, and walking. Always ask your doctor before beginning any type of exercise program to make sure it is safe for your unique situation.

Embrace your pregnancy as a time you will soon miss. Even though your feet are swollen, you are constantly tired and never full, there will come a day when you miss it. Using the tips in this article will highlight the best parts and minimize the worst parts of your pregnancy so that your pregnancy will be a fond memory. We know you want to discover more about Tips for Getting Pregnant, and coming up next is something we believe will help you in ways you do not know, yet. The range of available information is staggering, and what I have found is most people easily get lost. It is through no fault of your own, but if you have not read a lot about it, then you do need to be cautious.

To get a grip on pertinent hints about Can you exercise while pregnant and even on Infertility definition, read this incredibly informative site.

Source: http://articlesbright.com/home-family/make-your-pregnancy-a-great-time-by-following-these-great-tips

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Nantucket Real Estate ? Blog Archive ? Property Transfers for the ...

A vacant lot on 1.5 acres at Rear of Plainfield Road sold to Langtry Investments, LLC of Chevy Chase, Md. from Kenneth C. Coffin, Inc. of Nantucket, Mass. for $1,100,000. The property is assessed at $950,400. The Land Bank fee is $22,000.

A house on .10 of an acre at 5 Warren St. sold to Stuart M. Duty and Mary A. Duty of Greenwich, Conn. from Barbara R. McKee of Greenwich, Conn. for $835,000. The property is assessed at $1,235,500. The Land Bank fee is $16,500.

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This entry was posted on Tuesday, February 21st, 2012 at 11:12 am and is filed under Real Estate Transactions. You can follow any responses to this entry through the RSS 2.0 feed. You can leave a response, or trackback from your own site.

Source: http://www.nantucketrealestate.com/NantucketRealEstate/?p=3802

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Decorate Your Home Using Terracotta Warriors | Home ...

Have you ever heard about Terracotta Warriors? Maybe it is the first time you hear about Terracotta Warriors. Terracotta Warriors and Horses is a clay army of more than 8,000 life-size terracotta figures of soldiers and horses that discovered in 1974 in China. But, what is the relationship between Terracotta Warriors and decorating our home?

You can get them and put them in your garden home or other places. Now you can buy Terracotta Warriors via internet. When you surfing on the internet you know find out more about Terracotta Warriors and you can feel how they are very interesting.

There are many kinds of statutes that you can choose to decorate your home or your garden. There are new products such as Armored Warrior II, Armored Warrior, Bearded General, Kneeling Archer, Sworded General, Emperor Qin Shi Huang Di are offered in special prices. You can use these special offers to get your favorite statues.

Make your home so unique with Terracotta Warriors. If you like Chinese statue, you can get some like Emperor Qin Shi Huang Di?s warriors. Or are you interested in other famous warriors?? Having put the warriors? replica at home, you can show to your friends or relatives when they visit you. It is really nice to have your favorite things at your home now.

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4. Decorate Your House with Beaded Curtain
5. Decorate Your Living Room

Source: http://www.salleywags.com/decorate-your-home-using-terracotta-warriors/

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Bottlenose 2.0: Taming The ?Share-pocalypse? With A Smarter Social Media Dashboard

There's a lot of noise in our social media channels. I'm busy clogging up your Twitter feed with my deep thoughts, your friends are sharing their one-millionth baby picture on Facebook, and Scoble is filming startups in your living room on Google+. There is unfathomable amount of data being produced every second, as social networks, apps, chat, etc. now facilitate realtime communication and sharing -- making email feel like the Pony Express. This makes it nearly impossible for people (and their businesses) to stay on top of -- among other things -- the realtime communication happening between their customers.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/C0m5y6uwgd0/

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